My review of Prime Joint Support
5 out of 5 star rating. 
Strong Bones & Flexible Joints
200+
The human body has more than 200 bones and more than 200 joints that connect those bones.
21.1%
of Americans above 18 years old reported joint discomfort in a survey conducted in 2019–2021.
Women
reported higher percentages, 20.1% in comparison to men at 16.3%, regarding issues with joint health.
Formulated With the Super Antioxidant, Pycnogenol®‡
Pycnogenol®‡ is a water-soluble, flavonoid complex with powerful benefits. Extracted from the bark of the French Maritime Pine tree, Pycnogenol®‡ has been shown to help maintain the body’s natural defenses by inhibiting metabolic responses associated with the normal aging process. Additionally, studies have shown the ability of Pycnogenol®‡ to cross-link collagen fibers and strengthen connective tissue proteins.
Product Classification
Gluten-Free
No Detectable GMO
Isotonic
Good Manufacturing Practices
Prime Ingredients for Prime Joints
When choosing a joint health supplement, it’s common to see glucosamine, chondroitin and methylsulfonylmethane (MSM) among the main ingredients. Prime Joint is specifically formulated with hyaluronic acid, which has shown to be more bioavailable than chondroitin and provides the same benefits for tissue hydration, lubrication and cellular function as MSM in lower quantities. The addition of glucosamine and Pycnogenol®‡ supports synovial fluid, cushioning and nourishing your joints and provides antioxidant support, helping your body respond to the effects of normal aging. *
Key Ingredients & Benefits
Pine Bark Extract (Pycnogenol®‡)*
Promotes blood flow and joint comfort associated with the normal aging process
Helps maintain joint comfort
Hyaluronic acid*
Helps maintain strong, healthy cartilage
Promotes the body's healing process
Sodium (bicarbonate)*
Supports endurance and performance
Helps combat exercise fatigue
Glucosamine (HCI)*
Supports healthy joint function
Promotes the normal production of synovial fluid
Potassium (bicarbonate)*
Helps maintain fluid balance
Keep in Your Prime
Help keep your joints young with the only product available delivering glucosamine, Pycnogenol®‡ and hyaluronic acid in isotonic form for maximum absorption of nutrients.
Directions For Use
Pour 2 small capfuls (6.6 g) of Isotonix Prime Joint Support Formula powder into a cup.
Add 4 fl oz (120 ml) of water and mix thoroughly.
Take daily to maintain joint health. If mixed with other Isotonix products, add 2 oz (60 ml) of water for each capful.
Isotonix Delivery System
:05 Minutes
Isotonix Liquid Vitamins
- Formulated to survive digestion.
- Delivers concentrated nutrients to the site of absorption.
- Contains no fillers or binders.
- No artificial color or flavors.
:40 minutes
Standard Vitamin Tablet
- Contains lab-created coatings and lubricants.
- Often contains artificial colors, nutrients and flavors.
- Limited absorption of nutrient utilization.
Frequently Asked Questions
What other products should I take with Prime™ Joint Support Formula by Isotonix® to support my joint health?
Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.
How often should I take Prime Joint Support Formula by Isotonix?
This product is most effective when taken daily.
How much Pycnogenol®‡ is in Prime Joint Support Formula by Isotonix?
There are 25 mg of Pycnogenol®‡ in each daily serving.
What is the best way to store this product?
Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator — but not in the fruit and vegetables area.
Prime™ Joint Support Formula by Isotonix® Research Scope
558+
Studies on Pycnogenol®‡ and human health
* This product is not intended to diagnose, treat, cure or prevent any disease.
‡As Pycnogenol®. Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
Reviews
Break down of ratings: (56) 5 star ratings. (7) 4 star ratings. (1) 3 star ratings. (1) 2 star ratings. (2) 1 star ratings.
would recommend this product.
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I started Prime Joint Support in the last week of Oct 2025 and I felt that my knees became pain free after about 2+ weeks of taking it.
On 13 Nov I went to a party and I received a great compliment from a dance instructor telling me that I dance well. I must say this is only possible because I regain my mobility after consuming Prime Joint Support
Need a vegetarian version
2 out of 5 star rating.
Glucosamine has been around for a while and there are non-marine sources available. Please work on a vegan or at minimum vegetarian Joint Health supplement. Thank you.
Great joint support!
5 out of 5 star rating.
My husband and I have been taking this joint support for more than 4 years and our joints are well maintained! Shared with my 80+ year old friend and she found it helped with her knee pain also before and after her knee replacement surgery.
This works!
5 out of 5 star rating.
I was hesitant to try this at first, but my shop consultant convinced me to give it a shot—and wow, am I glad I did! This really works! The pain in my kneecap that I felt every time I walked down the stairs is finally gone. I’m honestly amazed!
Good for my joint
5 out of 5 star rating.
Good product for my joint. My knee is getting better and stronger after taking it for a while.
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