Powered by Ingredients with Clinically Relevant Science
Key research insights behind NMN, fisetin and spermidine.
NMN
Supports improvements in physical vitality in adults. Studies show that adults supplementing with NMN experienced improvements in walking speed, grip performance and sleep quality.
Spermidine (Yuth™)
Levels and the body’s ability to absorb it decline with age. Evidence suggests that healthy levels of this compound are associated with healthy aging and longevity.
Fisetin
has strong antioxidant activity and supports cellular health pathways related to healthy aging.
NMN — The Direct NAD+ Precursor
Engineered for fast uptake and powerful cellular support.
NMN is one of the closest precursors to NAD+, helping the body maintain healthy NAD+ levels as they naturally decline with age. Research shows orally administered NMN is absorbed rapidly and supports NAD+ production in key tissues. By helping maintain NAD+ availability, NMN supports mitochondrial function, energy production, metabolic function and cellular health against everyday stressors.
Product Classification
Good Manufacturing Practices
Vegan
No Detectable GMO
Gluten-Free
The Prime™ Approach to Cellular Support
Designed to fuel cellular vitality through multiple supportive pathways.
NMN, fisetin and spermidine each contribute to overall cellular health. NMN supports NAD+ metabolism and cellular energy, fisetin helps defend against oxidative stress and spermidine helps maintain cellular balance. Together, they provide broad foundational support for healthy aging.
Key Ingredients & Benefits
Supports Muscle Performance with Age*
Supports energy production in muscle tissue.
Supports Cognitive Function*
NMN and fisetin support cellular pathways involved in healthy brain function.
Antioxidant support from fisetin supports overall cellular health.
Helps Maintain Metabolic Health*
Spermidine intake is associated with healthy metabolic markers.
Supports metabolic health and helps maintain normal glucose levels.
Supports Antioxidant Activity*
Fisetin is a well-studied antioxidant that helps neutralize free radicals.
Spermidine and NMN support the body’s antioxidant defense systems.
Supports Cellular Energy*
NMN supports NAD+ metabolism, a cofactor essential for cellular ATP production.
Research shows NMN promotes NAD+ metabolites.
Fisetin helps support healthy mitochondrial function.
Spermidine supports overall cellular balance for efficient energy use.
Supports Healthy Aging*
NMN helps maintain NAD+ levels that decline with age.
Spermidine intake may correlate with healthy aging.
Fisetin promotes cellular antioxidant support.
The Future of Cellular Energy Starts Here
Keeping your cellular NAD+ levels at their peak is essential for vibrant energy, optimal mitochondrial functioning and graceful aging. Prime™ NMN harnesses cutting-edge science with a powerful trio of ingredients working in harmony to supercharge cellular health at the foundation while supporting your body’s antioxidant defenses. Choose Prime™ NMN — your partner in biohacking vitality for cellular resilience and a healthier tomorrow.
Frequently Asked Questions
How do Prime™ NMN and Prime™ NAD+ work differently to support NAD+ production?
NMN and NR are different NAD+ precursors that support the body’s NAD+ pool through distinct metabolic routes. The body regulates NAD+ production, so using both may offer a broader support profile, though more isn’t always better.
Will I benefit from taking both together?
Yes, NMN and NR supplementation support NAD+ levels in the body through different pathways. NMN is one step closer to NAD⁺ than NR. Pairing Prime™ NAD+ (formulated with NR and pterostilbene) with Prime™ NMN (formulated with NMN, fisetin and Yuth™—spermidine) could offer a broader longevity-supporting profile, exceeding NAD⁺ support.
If I take Prime NAD+, should I switch?
Both Prime NAD+ and Prime NMN support NAD+ production; the choice is based on preference for the specific precursor and additional support ingredients.
What products pair well with Prime™ NMN?
Isotonix OPC-3® supports oxidative balance and Isotonix® Activated B Complex helps provide B vitamin cofactors involved in NAD+ metabolism.
What daily amount of NMN supports healthy aging?
Research suggests NMN and NR support both men and women. Benefits relate more to age than gender.
Does this product support men and women equally?
Research suggests NMN and NR support both men and women. Benefits relate more to age than gender.
What are NAD+ precursors?
They are compounds that help maintain NAD+ production pathways, including NMN, NR, NAM, NA and tryptophan.
When is the best time to take it?
Most users take it in the morning with food, aligning with natural energy rhythms.
What else depletes NAD+ levels?
Lifestyle factors such as poor sleep, low activity, smoking, and alcohol can contribute to lower NAD+ levels.
Research Scope
Reference List
- ProHealth Longevity. Sirtuins and your health: ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Manager. (2024, October 29). The best NAD+ precursor, NMN, NR, NA or Trp? - Uthever®︎. Uthever®︎. https://www.uthever.com/the-best-nad-precursor-nmn-nr-na-or-trp/
- Gender difference: NAD+ loss significantly higher in middle-aged men than women – BYHEALTH study. (2022, June 13). NutraIngredients.com. https://www.nutraingredients.com/Article/2022/06/13/nad-loss-significantly-higher-in-middle-aged-men-than-women-byhealth-study/
- Download Center - Uthever®︎: NMN White Paper. (n.d.). Uthever®︎. https://www.uthever.com/about-us/download-center/
- Nguyen, A. (2025, September 23). Why you can’t take NAD+ directly—and the best precursor to boost NAD+ effectively. AboutNAD. https://www.aboutnad.com/blogs/blog/why-you-can-t-take-nad-directly-and-the-best-precursor-to-boost-nad-effectively
- Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., & Imai, S. I. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. Nature metabolism, 1(1), 47–57. https://doi.org/10.1038/s42255-018-0009-4
- Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., ... & Itoh, H. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine journal, 67(2), 153-160.
- Hsu, C. P., Yamamoto, T., Oka, S., & Sadoshima, J. (2014). The function of nicotinamide phosphoribosyltransferase in the heart. DNA repair, 23, 64–68. https://doi.org/10.1016/j.dnarep.2014.08.005
- com. (n.d.). https://www.nad.com/news/nmn-increases-nad-enhances-physical-performance
- Elysium Health. (2022, November 18). Benefits of NMN supplementation: From day 1 to 6 months. https://www.elysiumhealth.com/blogs/aging101/benefits-of-nmn
- Kelsey. (2023, March 20). What is YüthTM from Compound Solutions? - Compound Solutions. Compound Solutions. https://compoundsolutions.com/what-is-yuth-from-compound-solutions/
- Currais, A., Farrokhi, C., Dargusch, R., Armando, A., Quehenberger, O., Schubert, D., & Maher, P. (2017). Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(3), 299.
- Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: A Dietary Antioxidant for Health Promotion. ANTIOXIDANTS & REDOX SIGNALING, 19(2).
- Klimova, N., Long, A., & Kristian, T. (2019). Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3 dependent mechanism in male mice. Journal of neuroscience research, 97(8), 975.
- Shade, C. (2020). The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine: A Clinician's Journal, 19(1), 12.
- Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell metabolism, 27(3), 513-528.
- (2024, September 27). Synergy of NMN, resveratrol and spemidine. How they all work together for anti-aging? - Rescence. https://rescence.com/synergy-of-nmn-resveratrol-spermidine/
*This product is not intended to diagnose, treat, cure or prevent any disease.
†As Yuth. Yuth™ is a trademark of Compound Solutions.
Reviews
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would recommend this product.
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I have started using NAD+ for more than a year, and now added NMN to my daily regime. My daily schedule is full as I have a full time job and at same time run my own online business. I need the focus, energy, and stamina to finish what I set to do daily. I can feel it helps me to sleep better, & recover faster from my tennis games too!
You Look Younger!
by NGE
Shop Consultant
on 15/5/2026
Just two days ago, a friend from Indonesia met me and asked
'Why do you look younger? That really caught my attention. On top of that, i also noticed my hair feels stronger and healthier, with significantly less hair fall after showering or even during my morning combing.
NMN
by Anonymous
on 1/5/2026
My intake every morning 2 NMN together with 2 NAD
Power up in my alertness and memory thru out the day without tiredness.
Being praise by my friends, Me getting younger and looking great on me.
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