Help Protect the Body from Negative Effects of Free Radicals
8
Formulated with 8 antioxidant-supporting ingredients
Antioxidants contribute to overall wellness as part of a balanced lifestyle.
Antioxidants United, Stronger Together
Support your body’s natural defenses with a variety of antioxidants. Different antioxidants play unique roles, and when combined, they work together to help maintain overall well-being. By choosing a diverse mix of antioxidants, you can enjoy complementary benefits that contribute to your daily health.
Antioxidant and Herbal Defense for Skin Health
Give your skin the support of essential nutrients, including vitamins C and A, which help maintain collagen formation and contribute to overall skin well-being. Choose Timeless Prescription® Oxygen Extreme™ as part of your daily routine to support skin health from within.
Product Classification
Gluten-Free
No Detectable GMO
Good Manufacturing Practices
Key Ingredients & Benefits
Vitamins E, C and A (Beta-Carotene)
Vitamin E protects the body from oxidation and neutralizes free radicals.
Vitamin C helps to maintain healthy collagen in the skin and promotes normal healing.
Vitamin A helps to promote healthy skin and vision.
Bilberry
Acts as a powerful antioxidant
Supports healthy circulation in the body
Strengthens the structural integrity of blood vessels
Promotes healthy circulation to small capillaries that deliver oxygen and nutrients to the eyes, skin and tissues
Ginkgo Biloba
Supports circulation, oxygenation and blood flow to skin and tissues
Milk Thistle
Used to promote liver health, containing some of the most potent liver-supporting substances known
Protects against free radicals by acting as an antioxidant
Selenium
Acts synergistically with vitamin E
Promotes the body’s production of glutathione peroxidase, the body's master antioxidant
Green Tea Extract
Possesses potent antioxidant activity
Frequently Asked Questions
How are free radicals formed?
Normally, bonds don’t split in a way that leaves a molecule with an odd, unpaired electron; however, when weak bonds split, free radicals are formed. Free radicals are very unstable and react quickly with other compounds, trying to capture the needed electron to gain stability. Generally, free radicals attack the nearest stable molecule, stealing its electron. When the attacked molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell. Some free radicals arise normally during metabolism. Sometimes the body’s immune system cells purposefully create them to neutralize viruses and bacteria. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also spawn free radicals. The body can usually handle free radicals, but if antioxidants are unavailable or if free radical production becomes excessive, oxidation can occur. Of particular importance is that oxidation caused by free radicals accumulates with age.
How can the use of antioxidants fight against free radicals?
Vitamins C and E are thought to protect the body against the negative effects of free radicals. Antioxidants neutralize free radicals by donating one of their own electrons, ending the electron-stealing reaction. The antioxidant nutrients themselves don’t become free radicals by donating an electron because they are stable in either form; rather, they act as scavengers, helping neutralize free radicals. Vitamin E is the most abundant fat-soluble antioxidant in the body. It is one of the most efficient, chain-breaking antioxidants available. It is a primary defender against oxidation and lipid peroxidation (creation of unstable molecules containing more oxygen than is usual). Vitamin C is the most abundant water-soluble antioxidant in the body. It acts primarily in cellular fluid. It is particularly effective in combating free-radical formation caused by pollution and cigarette smoke. It also helps return vitamin E to its active form.
What foods contain antioxidants?
Fruits and vegetables contain the most antioxidants. The problem is that when we process fruits and vegetables, many of the antioxidants are reduced. So, even eating a diet high in fruits and vegetables cannot guarantee you will get enough antioxidants, but it is still a good place to start.
What is the best antioxidant to take?
The best way to fight free radicals is with a collection of antioxidants. There is not one single antioxidant that is most effective. In order to be effective there must be a team of antioxidants all working together. When you supplement with a team of antioxidants you will find that the whole is greater than the sum of its parts.
Are there any contraindications or warnings for this product?
If you are currently using prescription medications, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product. If you are currently taking blood thinning medicines (e.g. aspirin, warfarin) or if you have bleeding tendency, consult your healthcare provider before using this product as ginkgo may increase the risk of bleeding. This product contains green tea extract with rare reported cases that may lead to potential liver issue, if you have or have had liver problems or have concern on taking green tea extract, please consult your healthcare provider.
Is Timeless Prescription Oxygen Extreme manufactured in a Good Manufacturing Practice (GMP) facility?
Yes, this product is manufactured in a GMP-compliant facility which is inspected by the Food and Drug Administration (FDA) in the U.S.A.
Research Scope
Abe, K., et al. Green Tea with a High Catechin Content Suppresses Inflammatory Cytokine Expression in the Galactosamine-injured Rat Liver. Biomedical Research. 26(5): 187-192, 2005.
Alaluf, S., et al. Dietary Carotenoids Contribute to Normal Human Skin Color and UV Photosensitivity. Journal of Nutrition. 132: 399-403, 2002.
Atalay, M., et al. Anti-angiogenic Property of Edible Berry in a Model of Hemangioma. Federation of European Biochemical Societies. 544: 252-257, 2003.
Bagchi, D. Anti-angiogenic, Antioxidant, and Anti-carcinogenic Properties of a Novel Anthocyanin-Rich Berry Extract Formula. Biochemistry (Moscow). 69(1): 75-80, 2004.
Beppu, M., et al. Water-soluble Antioxidants Inhibit Macrophage Recognition of Oxidized Erythrocytes. Biological & Pharmaceutical Bulletin. 24(5): 575-578, 2001.
Bettuzzi, S., et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-grade Prostate Intraepithelial Neoplasia: a Preliminary Report from a One-year Proof-of-Principle Study. Cancer Research. 66(2): 1234-1240, 2006.
Chan, D., et al. Regulation of Procollagen Synthesis and Processing during Ascorbate-induced Extracellular Matrix Accumulation In Vitro. Biochemical Journal. 269: 175-181, 1990.
Chao, J. and Chu, C. Effects of Ginkgo biloba Extract on Cell Proliferation and Cytotoxicity in Human Hepatocellular Carcinoma Cells. World Journal of Gastroenterology. 10(1): 37-41, 2004.
Chao, J., et al. Effects of Ginkgo biloba Extract on Cytoprotective Factors in Rats with Duodenal Ulcer. World Journal of Gastroenterology. 10(4): 560-566, 2004.
Craig, W. Health-promoting Properties of Common Herbs. American Journal of Clinical Nutrition. 70(3): 491S-499S, 1999.
Davidson, J., et al. Ascorbate Differentially Regulates Elastin and Collagen Biosynthesis in Vascular Smooth Muscle Cells and Skin Fibroblasts by Pretranslational Mechanisms. Journal of Biological Chemistry. 272 (1): 345-352, 1997.
Davis-Searles, P., et al. Milk thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum Marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells. Cancer Research. 65(10): 4448- 4457, 2005.
de Almeida Vasconcelos Fonseca, E., et al. All-trans and 9-cis Retinoic Acids, Retinol and Beta-carotene Chemopreventive Activities during the Initial Phases of Hepatocarcinogenesis Involve Distinct Actions on Glutathione S-transferase Positive Preneoplastic Lesions Remodeling and DNA Damage. Carcinogenesis. 26(11): 1940-1946, 2005.
Dhingra, S. and Bansal, M. Hypercholesterolemia and Apolipoprotein B Expression: Regulation by Selenium Status. Lipids in Health and Disease. 4: 28, 2005.
Ellis, G., et al. Neutrophil Superoxide Anion–generating Capacity, Endothelial Function and Oxidative Stress in Chronic Heart Failure: Effects of Short- and Long-term Vitamin C Therapy. Journal of the American College of Cardiology. 36: 1474 – 1482, 2000.
Engelhart, M. Dietary Intake of Antioxidants and Risk of Alzheimer Disease. The Journal of the American Medical Association. 287:3223-3229, 2002.
Garcia-Casal, M., et al. Vitamin A and Beta-carotene Can Improve Nonheme Iron Absorption from Rice, Wheat and Corn By Humans. Journal of Nutrition. 128(3): 646-650, 1998.
Gonzalez, S., et al. Dietary Lutein/Zeaxanthin Decreases Ultraviolet B-Induced Epidermal Hyperproliferation and Acute Inflammation in Hairless Mice. Journal of Investigative Dermatology. 121: 399-405, 2003.
Gu, M., et al. Silibinin Inhibits Ultraviolet B Radiation-induced Mitogenic and Survival Signaling, and Associated Biological Responses in SKH-1 Mouse Skin. Carcinogenesis. 26(8): 1404-1413, 2005.
Gu, M., et al. Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, Mitogen-Activated Protein Kinases, and Akt Signaling. Cancer Research. 64: 6349-6356, 2004.
He, S., et al. Effects of Extract from Ginkgo biloba on Carbon Tetrachloride-induced Liver Injury in Rats. World Journal of Gastroenterology. 12(24): 3924-3928, 2006.
Head, K. Natural Therapies for Ocular Disorders, Part Two: Cataracts and Glaucoma. Alternative Medicine Review. 6(2): 141-166, 2001.
Heinrich, U., et al. Supplementation with {beta}-Carotene or a Similar Amount of Mixed Carotenoids Protects Humans from UV-Induced Erythema. Journal of Nutrition. 133(1): 98-101, 2003.
Hsu, S. and Dickinson, D. A New Approach to Managing Oral Manifestations of Sjogren's Syndrome and Skin Manifestations of Lupus. Korean Society for Biochemistry and Molecular Biology. 39(3): 229-239, 2006.
Huang, H., et al. Effects of Vitamin C and Vitamin E on In Vivo Lipid Peroxidation: Results of a Randomized Controlled Trial. American Journal of Clinical Nutrition. 76: 549 – 555, 2002.
Huang, S., et al. Effect of Ginkgo biloba Extract on Livers in Aged Rats. World Journal of Gastroenterology. 11(1): 132-135, 2005.
Ito, Y., et al. Cardiovascular Disease Mortality and Serum Carotenoid Levels: a Japanese Population-based Follow-up Study. Journal of Epidemiology. 16(4): 154-160, 2006.
Jang, Y., et al. Anthocyanins Protect against A2E Photooxidation and Membrane Permeabilization in Retinal Pigment Epithelial Cells. Photochemistry and Photobiology. 81(3): 529-536, 2005.
Jia, X. and Han, C. Chemoprevention of Tea on Colorectal Cancer Induced by Dimethylhydrazine in Wistar Rats. World Journal of Gastroenterology. 6(5): 699-703, 2000.
Kidd, P. A Review of Nutrients and Botanicals in the Integrative Management of Cognitive Dysfunction. Alternative Medicine Review. 4(3): 144-161, 1999.
Kim, H., et al. Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase Activities. Bioscience, Biotechnology, and Biochemistry. 68(9): 1977-1979, 2004.
Kren, V. and Walterova, D. Silybin and Silymarin—New Effects and Applications. Biomedical Papers. 149(1): 29-41, 2005.
Kupka, R., et al. Selenium Status is Associated with Accelerated HIV Disease Progression among HIV-1-infected Pregnant Women in Tanzania. Journal of Nutrition. 134: 2556-2560, 2004.
Lasse, M., et al. Anthocyanins Induce Cell Cycle Perturbations and Apoptosis in Different Human Cell Lines. Carcinogenesis. 25(8): 1427-1433, 2004.
Li, L., et al. Silibinin Prevents UV-Induced HaCaT Cell Apoptosis Partly through Inhibition of Caspase-8 Pathway. Biological & Pharmaceutical Bulletin. 29(6): 1096-1101, 2006.
Logan, A. and Wong, C. Chronic Fatigue Syndrome: Oxidative Stress and Dietary Modifications. Alternative Medicine Review. 6(5): 450-459, 2001.
Manna, S. Silymarin Suppresses TNF-induced Activation of NF-kappa B, c-Jun N-terminal Kinase, and Apoptosis. Journal of Immunology. 163(12): 6800-6809, 1999.
Mantena, S., et al. Orally Administered Green Tea Polyphenols Prevent Ultraviolet Radiation-Induced Skin Cancer in Mice through Activation of Cytotoxic T Cells and Inhibition of Angiogenesis in Tumors. Journal of Nutrition. 135: 2871-2877, 2005.
Mayne, S. Antioxidant Nutrients and Chronic Disease: Use of Biomarkers of Exposure and Oxidative Stress Status in Epidemiologic Research. Journal of Nutrition. 133: 933S-940S, 2003.
McArdle, F., et al. Effects of Oral Vitamin E and ß-carotene Supplementation on Ultraviolet Radiation–induced Oxidative Stress in Human Skin. American Journal of Clinical Nutrition. 80(5): 1270-1275, 2004.
Nakajima, J., et al. LC/PDA/ESI-MS Profiling and Radical Scavenging Activity of Anthocyanins in Various Berries. Journal of Biomedicine and Biotechnology. 2004(5): 241-247, 2004.
Ogasawara, M., et al. Differential Effects of Antioxidants on the In Vitro Invasion, Growth and Lung Metastasis of Murine Colon Cancer Cells. Biological & Pharmaceutical Bulletin. 30(1):200-204, 2007.
Ohta, Y., et al. Effect of Oral Vitamin E Administration on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator. Biological & Pharmaceutical Bulletin. 29 (4):675-683, 2006.
Paleologos, M., et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.
Park, Y., et al. Preventive Effect of Ginkgo biloba Extract (GBB) on the Lipopolysaccharide-induced Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 via Suppression of Nuclear Factor-kappa B in RAW 264.7 Cells. Biological & Pharmaceutical Bulletin. 29(5): 985-990, 2006.
Pence, B., et al. Effects of Dietary Selenium on UVB-Induced Skin Carcinogenesis and Epidermal Antioxidant Status. Journal of Investigative Dermatology. 102: 759-761, 1994.
Placzek, M., et al. Ultraviolet B-Induced DNA Damage in Human Epidermis Is Modified by the Antioxidants Ascorbic Acid and D-alpha-Tocopherol. Journal of Investigative Dermatology. 124: 304-307, 2005.
Ravindranath, M., et al. Epicatechins Purified from Green Tea (Camellia Sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines. Evidence Based Complementary and Alternative Medicine. 3(2): 237-247, 2006.
Ruggiero, P., et al. Red Wine and Green Tea Reduce H pylori- or VacA-induced Gastritis in a Mouse Model. World Journal of Gastroenterology. 13(3): 349-354, 2007.
Salonen, R., et al. Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. 107: 947 – 953, 2003.
Sato, Y., et al. The Feeding of β-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice. Biological & Pharmaceutical Bulletin. 27(7): 978-984, 2004.
Shen, X., et al. Effects of Dietary Supplementation with Vitamin E and Selenium on Rat Hepatic Stellate Cell Apoptosis. World Journal of Gastroenterology. 11(32): 4957-4961, 2005.
Simon, J., et al. Relation of Serum Ascorbic Acid to Mortality among US Adults. Journal of the American College of Nutrition. 20: 255-263, 2001.
Singh, R., et al. Dietary feeding of Silibinin Inhibits Advance Human Prostate Carcinoma Growth in Athymic Nude Mice and Increases Plasma Insulin-like Growth Factor-binding Protein-3 Levels. Cancer Research. 62(11): 3063-3069, 2002.
Sparrow, J., et al. A2E-epoxides Damage DNA in Retinal Pigment Epithelial Cells. Vitamin E and Other Antioxidants Inhibit A2E-epoxide Formation. Journal of Biological Chemistry. 278(20): 18207-18213, 2003.
Trevithick-Sutton, C., et al. The Retinal Carotenoids Zeaxanthin and Lutein Scavenge Superoxide and Hydroxyl Radicals: A ChemilumInescence and ESR Study. Molecular Vision. 12: 1127-1135, 2006.
Tyagi, A., et al. Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G2-M Arrest, and Apoptosis. Clinical Cancer Research. 8(11): 3512-3119, 2002.
Vahlquist, A., et al. Vitamin A in Human Skin: II Concentrations of Carotene, Retinol and Dehydroretinol in Various Components of Normal Skin. Journal of Investigative Dermatology. 79: 94-97, 1982.
van der Brandt, P., et al. Toenail Selenium Levels and the Subsequent Risk of Prostate Cancer: a Prospective Cohort Study. Cancer Epidemiology Biomarkers & Prevention. 12: 866-871, 2003.
van Rooij, J., et al. Oral Vitamins C and E as Additional Treatment in Patients with Acute Anterior Uveitis: a Randomised Double Masked Study in 145 Patients. British Journal of Ophthalmology. 83: 1277-1282, 1999.
Varghese, L., et al. Silibinin Efficacy against Human Hepatocellular Carcinoma. Clinical Cancer Research. 11: 8441-8448, 2005.
Wang, Z., et al. Inhibitory Effects of Black Tea, Green Tea, Decaffeinated Black Tea, and Decaffeinated Green Tea on Ultraviolet B Light-induced Skin Carcinogenesis in 7, 12-Dimethylbenz[a]anthracene-initiated SKH-1 Mice. Cancer Research. 54(13): 3428-3435, 1994.
Wei, W., et al. Prospective Study of Serum Selenium Concentrations and Esophageal and Gastric Cardia Cancer, Heart Disease, Stroke, and Total Death. American Journal of Clinical Nutrition. 79(1): 80-85, 2004.
Wertz, K., et al. ẞ-Carotene Interferes with Ultraviolet Light A-Induced Gene Expression by Multiple Pathways. Journal of Investigative Dermatology. 124: 428-434, 2005.
Xu, A., et al. Therapeutic Mechanism of Ginkgo biloba Exocarp Polysaccharides on Gastric Cancer. World Journal of Gastroenterology. 9(11): 2424-2427, 2003.
Yoshida, M., et al. Combined Effect of Vitamin E and Insulin on Cataracts of Diabetic Rats Fed a High Cholesterol Diet. Biological & Pharmaceutical Bulletin. 27(3): 338-344, 2004.
You, W. Gastric Dysplasia and Gastric Cancer: Helicobacter pylori, Serum Vitamin C, and Other Risk Factors. Journal of the National Cancer Institute. 92(19): 1607-1612, 2000.
Zhang, X., et al. Effect of Tea Polyphenol on Cytokine Gene Expression in Rats with Alcoholic Liver Disease. Hepatobiliary & Pancreatic Disease International. 5(2): 268-272, 2006.
Zhou, B., et al. Silibinin Protects Rat Cardiac Myocyte from Isoproterenol-Induced DNA Damage Independent on Regulation of Cell Cycle. Biological & Pharmaceutical Bulletin. 29(9): 1900-1905, 2006.
Zigman, S. Effects of Green Tea Polyphenols on Lens Photooxidative Stress. Biological Bulletin. 197: 285-286, 1999.
*This product is not intended to diagnose, treat, cure or prevent any disease.
Warning: If you are currently using any prescription drugs, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product.
Reviews
Customer Rating
5.0 out of 5 star rating.
(55 reviews)
would recommend this product.
- Newest
- Highest Rating
- Lowest Rating
- Oldest
- Most Helpful
Oxygen Extreme has really helped improve my overall health and skin condition. I used to experience frequent pimple breakouts on my back, but after taking it consistently for a few months, I noticed a significant reduction in my back acne.
It has also helped improve my fatty liver condition, which was something I was concerned about. Whenever I consume alcohol, I make sure to take it as part of my routine to help support and protect my liver.
This has definitely become one of the supplements I trust for both my skin and overall wellness.
My Go-To Comprehensive Bottle of Wellness
by HO
Shop Consultant
on 20/2/2026
From the first time I received this as a gift in 2004, I have never left home without taking two tablets of these!
It's such a comprehensive product, and helps in so many of our bodily functions for our liver, skin, bones, thyroid, brain, and so many more. Wellness in a single bottle!
Say Goodbye to Sleepless Nights
by Eio
on 15/12/2024
I used to struggle with waking up between 2-3 am and finding it impossible to fall back asleep. Since taking Timeless Prescription® Oxygen Extreme, I've been able to sleep through the night for 7-8 hours and wake up feeling much more energized. This product has truly improved my sleep quality and I highly recommend it to anyone struggling with similar issues."
Great for people that stays up late at night
by ho
Shop Consultant
on 21/10/2024
one of my latest favourite night regime! Works really well for people that stays up late, i notice taking this on a daily basis before sleep, helps to reduce my skin outbreaks
Oxygen
by Anonymous
on 29/6/2024
Oxygen is a great product, it helps to improve my skin and liver.
Share this page!
Copy this link and paste to your favorite social, blog or website.
Link copied! Please paste and share on your favorite platforms.
There was an error copying to your clipboard. Please try again later.